The triad of GLUT4-RBP4-STRA6 may play an important role in the pathogenesis of type 2 diabetes, wherein the adipocyte specific down regulation of GLUT4 leads to an increased expression of RBP4 and this increase in RBP4 expression leads to insulin resistance via STRA6. This evidence concerns the gene RBP4 and type 2 diabetes mellitus.