This difference in the kinetics of induction of AID expression by these two viruses may be due to EBV having to infect B cells and express viral proteins (i.e., LMP1) in order to induce AID expression, while HIV may induce AID expression more quickly, because it does so by direct CD40L:CD40 stimulation, which does not require viral infection. This evidence concerns the gene CD40LG and viral infectious disease.