It is evident from this depiction that the mRNAs for several of the enzymes of ST biosynthesis--most notably GalCer synthase (also called ceramide galactosyltransferase, UGT8) and GalCer sulfotransferase (Gal3ST1)--are higher for the ovarian carcinoma cells versus normal stromal tissue, whereas those for ST turnover are not different (arylsulfatase, ARSA, galactosylceramidase, GALC, and possibly the related saposins, based on the pro-saposin mRNA PSAP). The gene discussed is UGT8; the disease is ovarian carcinoma.