This response was strongest for ephrin-B1 +EphB2 and ephrin-B1 + EphB3 with the response from ephrin-B1 and EphB4 only producing minor modifications in cell distribution and compartmentalization in the DLD1 colorectal adenocarcinoma and Co115 colon carcinoma cells lines used in that study. The gene discussed is EPHB3; the disease is colon carcinoma.