EPHB4 and invasive carcinoma: HT29 cells have very low levels of EphB3 and EphB2 [36], whether the increase in EphB4 protein expression after exposure to EPA was sufficient to induce the compartmentalization response would require further work However this could suggest a mechanism by which the increase in EphB4 protein expression after exposure to EPA in HT29 cells might be beneficial in terms of halting cancer progression from adenoma through to invasive carcinoma.