Harris and Sephton showed that the uptake of radiogallium by malignant cell lines in vitro could be significantly enhanced by the addition of transferrin to the culture medium [57]; the clinical relevance of this finding was underscored by the studies of Vallabhajosula et al. who showed that in the blood radiogallium binds to transferrin and is transported to tumor tissue [56]. Here, TF is linked to neoplasm.