TP53 and neoplasm: A clearerunderstanding of the mechanisms controlling SOCS1 nuclear localization would becrucial to determine how SOCS1 mediates its tumor suppressor activity.Post-translational modifications like ubiquitination and phosphorylation thathave been shown to control the nuclear localization of p53 [65,66,67] and STAT[68] could also control the nucleo-cytoplasmic shuttling of SOCS1.