This adaphostin-induced HMOX1 upregulation in NCI-H522 cells and glioblastoma cell lines [6] is in contrast to the response of hematologic cell lines where we have previously reported the major transcriptional response involved >10-fold induction of genes encoding for both heavy and light ferritin polypeptides (FTH and FTL) [3]. Here, HMOX1 is linked to glioblastoma.