In order to inhibit LMP1 activity a dominant negative mutant of LMP1 which is defective in the LMP1 induced signalling pathways, termed LMP1AAAG, fused to GFP [16] denoted here as GFPdnLMP1 (or dnL as designation for transfected cells and clones) was introduced into the transgenic carcinoma cell lines. This evidence concerns the gene DNASE2 and carcinoma.