We hypothesized that the MYC gene might represent the master regulatory hub targeted by both oncogenic lesions because TLX1+ T-ALLs exhibit increased levels of MYC and MYC target genes [33,60] and NOTCH1 directly activates the MYC gene at the transcriptional level in T-ALL [14,15]. The gene discussed is TLX1; the disease is acute lymphoblastic leukemia.