TLX1 and acute lymphoblastic leukemia: Strikingly, the lists of GSI-responsive genes and TLX1-responsive genes overlapped very strongly: more than 60% of the GSI-responsive genes were also controlled by TLX1 (Figure 2A), indicating that a significant fraction of NOTCH target genes in ALL-SIL cells is coregulated by TLX1 (P < 0.0001).