TLX1 and acute lymphoblastic leukemia: To quantitatively compare the individual contributions of TLX1 and NOTCH in the regulation of common targets, we identified those genes that are differentially expressed in ALL-SIL cells where TLX1 and NOTCH are "on" versus cells where both factors are "off" (i.e., GSI-treated TLX1Low cells) (Additional file 3).