In addition, although calpains [31], [32], caspases [26], [33], [34], [35], and cathepsins [36], [37], [38], [39] can mediate Bid cleavage and have been implicated in apoptosis induction by reovirus [15], [16], [40], the precise identity of the protease that generates tBid following reovirus infection is not known. This evidence concerns the gene CTSS and Reoviridae infectious disease.