Given the importance of cholesterol for a number of aspects of HIV-1 biology, including virus binding and infection [42], [43], [44], [45], [47], [48], [49], [50], [51], [76], we hypothesized that PPARγ and LXR signaling was altering the cholesterol content of DC membranes, thereby rendering them incapable of efficiently binding HIV-1 particles. This evidence concerns the gene PPARG and infection.