Furthermore, NR signaling can inhibit HIV-1 transfer by previously matured DCs (Figure 4C) These results suggest that PPARγ and LXR signaling alter other pathways involved with HIV-1 trans-infection that are independent of the maturation state of the DC (Figure 4C), however we cannot rule out the possibility that the prevention of DC maturation may contribute to the NR-mediated decrease in HIV-1 capture and transfer. The gene discussed is PPARG; the disease is infection.