TLR4 and infection: In addition, PPARγ and LXR treatment also prevented the release of the chemokines MIP-1α and RANTES, which are important for the recruitment of CD4+ T cells to sites of infection, both from MDDC in response to the TLR4 ligand LPS (Figure 1C) and from plasmacytoid DCs (pDCs) in response to the TLR7 ligand CLO97 and the TLR9 ligand CpG ODN 2006 (Figure 1D).