To identify the genetic variants affecting susceptibility to leprosy, we conducted a population based case-control association study using a gene-centric 50 K microarray covering variants in 2,092 genes throughout the genome [5], and found TLR1 and HLA-DRB1/DQA1 as major determinants of leprosy susceptibility. Here, HLA-DQA1 is linked to leprosy.