CD4 and fungal infectious disease: In multivariate Cox models using time-varying covariates, lower baseline CD4+ T-cell count (HR = 0.79 per 10 additional CD4+ cells/μL; 95% CI: 0.65, 0.97; p = 0.022), higher CD4+ T-cell counts on ART (HR = 1.08 per additional 10 CD4+ cells/μL; 95% CI: 1.03, 1.13; p = 0.002), and the presence of a baseline non-PCP fungal infection (HR = 3.01; 95% CI: 1.16, 7.80; p = 0.023) were significantly associated with the development of IRIS (Table 4).