Larger change in CD4+ percentage (HR = 3.52 per additional 10 increase in CD4%; 95% CI: 1.50, 8.27 ; p = 0.004) and non-PCP fungal infections (HR = 2.87; 95% CI 1.13, 7.29; p = 0.026) were both significantly associated with the development of IRIS, while low baseline CD4+ percentage did not reach significance in this model (HR = 0.36 per additional 10 increase in CD4%; 95% CI: 0.11, 1.16; p = 0.086). The gene discussed is CD4; the disease is fungal infectious disease.