Lower baseline CD4+ percentage (HR = 0.17 per additional 10 increase in CD4%; 95% CI: 0.04, 0.69; p<0.001), higher CD4+ percentage on ART (HR = 3.90 per additional 10 increase in CD4%; 95% CI: 1.79, 8.47; p = 0.012) and baseline non-PCP fungal infection (HR = 3.08; 95% CI:1.20, 7.89; p = 0.019) were also significantly associated with IRIS. This evidence concerns the gene CD4 and pneumocystosis.