TLR4 and infection: Figure 7D, E illustrate that as with TLR2−/− mice, there were no significant differences in corneal opacification, cellular infiltration or fungal RFP expression between TLR4−/− and C57BL/6 corneas; however, in marked contrast to TLR2−/− mice, significantly more CFU were recovered from TLR4−/− mice after 48h compared with C57BL/6 mice (Figure 7F), indicating an impaired ability of TLR4−/− mice to clear the infection, and suggesting a role for TLR4 in fungal killing.