SOD1 and Decreased total leukocyte count: Frequent symptoms of copper deficiency include hypocupremia, impaired iron mobilization, anemia, leukopenia, neutropenia, decreased superoxide dismutase (SOD) (particularly erythrocyte SOD (ESOD)), ceruloplasmin as well as cytochrome-c oxidase, but increased plasma cholesterol and LDL:HDL cholesterol and abnormal cardiac function [55–57].