One subgroup of patients in whom liver biopsy is most likely to be useful is those HCV-positive patients in whom aminotransferase levels remain persistently normal.[16] As is well known that ALT levels do not correspond accurately to the degree of hepatic fibrosis, in patients with persistently normal aminotransferase levels, the only way to reliably determine the extent and severity of liver disease and thus to make timely decisions regarding therapeutic interventions is to go for liver biopsy. The gene discussed is GPT; the disease is Hepatic fibrosis.