Six of the 14 programs (ALN-RSV, ALN-VSP, ALN-TTR, TD101, bevasiranib, Bcr-abl) have clear target validation, and the other eight programs address targets of significant interest (for example, p53 for kidney injury or RTP801 for age-related macular degeneration (AMD)), but lack robust prior validation. This evidence concerns the gene DDIT4 and age-related macular degeneration.