EGFR and glioma: Genome-wide profiling of archival glioma samples have revealed that Her1 (epidermal growth factor receptor, EGFR) expression and/or gene dosage is upregulated in >40% of all gliomas and ∼90% of WHO grade IV glioblastoma multiforme tumors (GBM)s [8], [9], [10], [11] as well as low grade oligodendroglial tumors [12] compared to normal adult brain.