Infections of N-PRRSV viruses resulted in fever and inflammatory response, as indicated by high expression of proinflammatory cytokines and chemokines, adhesion molecules, inflammatory enzymes and receptors, such as IL-1β, IL8, SELL, ICAM, CCL2, CXCL9, CXCL10, B2M, proteasomes, cathepsins. Here, IL1B is linked to infection.