Nonetheless, it is time to speculate that hyperhomocysteinemia contributes to elevate blood pressure in the pathogenesis of renal disease, for example, diabetic nephropathy, and PPARγ is an effective target molecule to regulate hypertension, at least in part, through the reduction of homocysteine, where renal insufficiency upregulates homocysteine. This evidence concerns the gene PPARG and hyperhomocysteinemia.