PPARG and diabetic kidney disease: Thus, the activation of PPARγ in diabetic nephropathy modulates inflammatory reaction, at least in three different mechanisms: (1) increases insulin sensitivity and reduces plasma glucose level, therefore reduces inflammation; (2) promotes tissue clearance of homocysteine level and thus, reduces oxidative stress and inflammation; (3) normalizes CSE enzymatic activity, thereby raises the possibility of endogenous H2S generation, which has been documented as an anti-inflammatory and antihypertensive gaseous molecule at physiological levels [88, 103].