In keeping with the earlier notion that i) mouse strains that have more UCP1-expressing adipocytes in their WAT depots are protected against diet-induced obesity [77]; [78] and ii) brown-like multilocular adipocytes expressing UCP1 are detected interspersed within white adipose tissue in humans [20]; [21]; [79], we suggest that factors influencing UCP1 expression in white adipose tissue are of particular importance for the regulation of energy balance and the development of obesity also in humans. The gene discussed is UCP1; the disease is Obesity.