UCP1 and obesity due to melanocortin 4 receptor deficiency: The importance of COX in diet-induced expression of UCP1 in iWAT and diet-induced thermogenesis is underscored by our demonstration that inclusion of the general COX inhibitor indomethacin in the diet augmented high-fat diet-induced obesity in Sv129 mice kept at thermoneutrality irrespectively of UCP1 expression in iBAT.