UCP1 and obesity due to melanocortin 4 receptor deficiency: In keeping with the earlier notion that i) mouse strains that have more UCP1-expressing adipocytes in their WAT depots are protected against diet-induced obesity [77]; [78] and ii) brown-like multilocular adipocytes expressing UCP1 are detected interspersed within white adipose tissue in humans [20]; [21]; [79], we suggest that factors influencing UCP1 expression in white adipose tissue are of particular importance for the regulation of energy balance and the development of obesity also in humans.