Nephropathy, a predisposing risk factor for hypertension, can be also ameliorated by PPARγ and PPARα, athough these renoprotective effects are due to antiinflammatory and vasoprotective PPARγ/PPARα properties and the reduction in the proinflammatory Ang II effects, and are independent of the systemic RAAS modulation. This evidence concerns the gene PPARG and Hypertension.