Aldosterone and Ang II can also act as paracrine factors, and influence inflammation, mitogenesis, apoptosis and cell growth, through which they contribute not only to the development of hypertension but also to its cardiovascular complications [16, 25–31], such as microvascular damage, glomerular inflammation, podocyte injury and left ventricular hypertrophy [32, 33]. This evidence concerns the gene AGT and hypertensive disorder.