INS and type 2 diabetes mellitus: Moreover a protective role of the Pro12Ala variant was reported in (a) patients with multiple sclerosis who show a disease later onset [39]; (b) male patients with coronary artery disease who show less severe and less generalized atherosclerosis with reduced morbidity and mortality of cardiovascular events [40]; (c) patients with type 2 diabetes who show higher insulin sensitivity [40].