Indeed, the astrocytoma cells harbor a low level of Dnmt1/PCNA/UHRF1 interaction, whereas these cells, highly proliferative, are supposed to harbor a high level of the Dnmt1/PCNA/UHRF1 interaction according to the idea that the maintenance DNA methylation is a DNA replication-dependent process [17], [18]. The gene discussed is UHRF1; the disease is astrocytoma (excluding glioblastoma).