Notably, the median frequency of the CCR7+ Treg subset was significantly higher in those that did not develop BOS than in those that did subsequently develop BOS (29.1% [14.3, 50.7] vs. 9.8% [7.8, 11.1] p = 0.04) (Figure 3). This evidence concerns the gene CCR7 and Buschke-Ollendorff syndrome.