Y2 receptors are known to regulate stress responses as well as activity of the hypothalamo-pituitary adrenal axis, with germline Y2 receptor ablation reducing anxiety [49], [54], [55], [56] and decreasing hypothalamic expression of corticotropin releasing hormone and the circulating concentrations of corticosterone in lean or obese (ob/ob or diet-induced obese) mice [27], [57]. Here, CRH is linked to Anxiety.