Figure 6E demonstrates the frequency CD8+ T cells that were Vα7.2+ MR1-dependent responses analyzed by donor infection status. When compared with uninfected subjects (mean = 0.092), those with active TB (mean = 0.011) had markedly diminished responses (p = 0.0025), whereas comparison with those with LTBI (mean = 0.185) revealed a less dramatic decrease (p = 0.0611). Here, CD8A is linked to tuberculosis.