Like all mammalian prion diseases, which include Creutzfeldt–Jakob disease (CJD), kuru and variant CJD (vCJD) in humans and bovine spongiform encephalopathy (BSE) in cattle, the central event in CWD infection is the post-translational conversion of the host-encoded, cellular prion protein (PrPC), to an abnormal isoform, designated PrPSc (Prusiner, 1998; Collinge & Clarke, 2007). This evidence concerns the gene PRNP and prion disease.