It is possible that tests such as p16INK4A, a tumor suppressor gene or Pro-ExC® that detects aberrant S-phase induction may prove more useful in this population.[26‐28] These tests appear to be markers of disease, rather than infection and may help identify those women requiring referral to colposcopy and those who may be safely managed in a more conservative manner. Here, CDKN2A is linked to infection.