CD4 and squamous cell intraepithelial neoplasia: There appears to be a higher risk of squamous intraepithelial lesion following a diagnosis of ASC-US in HIV-positive women, especially in women with low CD4 counts compared to HIV-negative women.[20] According to Solomon et al,[2] ASC-H should not form more than 10% of the total number of atypical squamous cells.