CD8+ T-cells have been associated with both cure and pathology in human leishmaniasis: An expanded CD8+ cell population was observed in the draining lymph node prior to ulcer development, implicating CD8 mediated immunity in the early containment of Leishmania infection.[85] An increase in responding CD8+ cells has been associated with cure of L. braziliensis CL.[86, 87] Exacerbated CD8+ activity, in addition to a poor regulatory response, could however, underlie an unfavorable fate with regard to MCL. Here, CD8A is linked to ulcer disease.