A model where immunoglobulin (IgG) promotes infection by inducing IL-10 was proposed by Kane and Mosser, who showed that IgG coated amastigotes (L. major) could ligate Fc-receptors on murine macrophages and induce IL-10 production.[67] In support of this models in vivo studies found that Fc-deficient mice infected with L. amazonensis produce less IL-10 and are less susceptible to infection.[93] Moreover, a regulatory role for B cells has been suggested in a VL model demonstrating that B cell depleted animal exhibit extensive neutrophil mediated pathology.[23]. This evidence concerns the gene IL10 and infection.