The use of aggressive insulin therapy aimed at achieving normoglycemia in critically ill patients has been shown by the van den Berghe group to reduce mortality significantly in critically ill, surgical patients with sepsis.[42] Among the other important findings of this trial was a dramatic reduction in the development of severe AKI that required RRT (8.2 versus 4.8%; P = 0.04) and a reduction in the number of patients who experienced a peak creatinine >2.5 mg / dl or a peak urea nitrogen of >54 mg / dl. Here, INS is linked to acute kidney injury.