The acute respiratory distress syndrome (ARDS) network had shown us that low tidal volume ventilation for ARDS patients reduced mortality.[45] In a rabbit model of ARDS, Imai et al. went a step further to demonstrate that low tidal volume ventilation led to less apoptosis of tubular cells and resultant AKI.[46] The protective effect on the kidneys was attributed to Fas ligand. Here, FASLG is linked to acute respiratory distress syndrome.