LCE3B and psoriasis: Deletions, insertions, duplications, and complex multi-site variants collectively termed copy number variations (CNVs) are found in all humans and are functionally important.[50] Associations between higher genomic copy number for beta-defensin genes on chromosome 8, and LCE3B and LCE3C members of the late cornified envelope (LCE) gene cluster on 1q21 and psoriasis were recently demonstrated.[51, 52] Interestingly, the deletion of LCE3C and LCE3B genes did not contribute to susceptibility to PsA.[53] Thus, LCE gene may be a “skin specific” genetic risk factor.