This agreed with previous study of Toyoda et al. 2002 that confirmed that NGF level correlates with the AD severity measured by two different scores; the objective severity score (SCORAD) and the Eczema Area and severity index (EASI).[10] They suggest that NGF systemically modulates the allergic response in AD, probably through interactions with cells of the immune-inflammatory component. This evidence concerns the gene NGF and Alzheimer disease.