It is well recognized that α-crystallins function like a chaperone and play a decisive role in the maintenance of the eye lens transparency.[24, 25] Conversely, it is well established that certain point mutations in αA- and αB-crystallin genes are linked with non-syndromic, hereditary human cataracts.[24, 25] So far, mutations in ex-1 of CRYAA gene have been reported in congenital cataracts like the W9X-mutation,[20] and the R49C mutation.[26] But there are no reports on CRYAA gene mutations in age-related cataracts. The gene discussed is CRYAA; the disease is Age-related cataract.