The delayed healing of gastric ulcers has been attributed to the ability of the Helicobacter pylori to produce angiogenic inhibitors, whereas, reduced VEGF levels are responsible for recurrent aphthous ulcerations.[19] Organ dysfunction occurring in pre-eclampsia is associated with lower levels of VEGF.[20] Many age-related diseases such as nephropathy[21] and bone loss[22] have been found to be associated with progressive loss of the microvasculature. The gene discussed is VEGFA; the disease is canker sore.