The bone is a large repository for many growth factors, including transforming growth factor-β (TGF-β), hepatocyte growth factor (HGF), endothelial growth factor (EGF), insulin-like growth factor (IGF), β-platelet-derived growth factor (PDGF), and fibroblast growth factor (FGF), and provides a rich environment for tumour cell growth (Bussard et al, 2008). This evidence concerns the gene IGF1 and neoplasm.