After controlling for these factors, axillary lymph node metastasis (hazard ratio (HR), 13.6; 95% CI, 4.6–63.3; P<0.0001) and HER2-positive disease (HR, 5.0; 95% CI, 1.3–19.3; P<0.019) remained significant independent predictors of recurrence (Table 4). This evidence concerns the gene ERBB2 and metastatic malignant neoplasm in the lymph nodes.