SIRT1 regulates the expression of endothelial adhesionmolecules via suppression of NF-κB signaling in vitro NF-κB plays a central role in inflammatoryprocesses and its signaling pathway is inhibited by SIRT1 via deacetylation [12,23].NF-κB induces expression of adhesion molecules and inflammatory cytokines,and endothelial-specific inhibition of the NF-κB pathway protects micefrom atherosclerosis [24]. The gene discussed is SIRT1; the disease is atherosclerosis.