The SESN1 (6q21) and SESN2 (1p35) loci are frequentlydeleted in a variety of human cancers [1,22,23], implicating loss of Sestrinsin tumor progression and suggesting that Sestrin-dependent inhibition of TORC1is critical for suppressing tumorigenesis spurred by age-dependent accumulationof damaged DNA. This evidence concerns the gene SESN2 and cancer.