TLN1 and melanoma: Surprisingly, expression of the GFP-talin1 R358A mutant largely rescued the talin1 knockdown phenotype in HUVEC, and the same mutant has recently been shown to support Mn2+-induced αVβ3-integrin clustering in B16 melanoma cells (Saltel et al., 2009), and integrin clustering in muscle (Tanentzapf and Brown, 2006).