As a positive control to demonstrate a general function of BMSCs, all of them, regardless of MM or non-MM source, were capable of robustly activating STAT3 DNA-binding activity in RPMI8226 cells ([28,35], Figure 1B and 1C), likely mediated by the significant levels of IL-6 secreted by both types of BMSCs (see below). This evidence concerns the gene STAT3 and Miyoshi myopathy.