NFKB1 and Miyoshi myopathy: This notion was further corroborated by our observation that CM from MM-BMSCs was also able to activate NF-κB in RPMI8226 cells and primary MM cells (Figures 3B and 3C, respectively), and concentration of the CM by size-exclusion with a cut-off at 3 kDa resulted in further induced NF-κB activity (Figure 3B).