A recent study comparing production of IL-8 by BMSCs derived from patients with monoclonal gammopathy of undetermined significance (MGUS), an asymptomatic disease of increased immunoglobulin secretion by plasma cells, smoldering MM, or active MM, found that IL-8 levels correlated positively with disease state [39]. The gene discussed is CXCL8; the disease is monoclonal gammopathy.