As the high-fat diet itself, independent of a gain in body fat, was associated with several factors associated clinically with osteoarthritis (that is, altered cartilage properties, grip strength, increased anxiety-like behavior, and adiponectin level), our findings suggest that diet modification, in and of itself, could potentially reduce some of the known risk factors for osteoarthritis-associated disability. Here, ADIPOQ is linked to osteoarthritis.