Regarding the chemokine release, IL-27 induced CXCL9 and CXCL10 from control FLS, CCL2 and CXCL10 from RA-FLS and CXCL9 from RA-FLS was found to be mediated by PI3K and JNK pathways, JAK, PI3K and JNK pathways, and JAK and PI3K pathways, respectively (Figure 7). This evidence concerns the gene CXCL9 and rheumatoid arthritis.