As shown in Figure 7, PI3K inhibitor LY294002 and JNK inhibitor SP600125 could significantly suppress IL-27-induced ICAM-1 expression on the cell surface of control FLS, and IL-27-induced ICAM-1 and VCAM-1 on RA-FLS (P < 0.05). This evidence concerns the gene MAPK8 and rheumatoid arthritis.