Mutations were also identified in brain metastases from non-breast primaries in EGFR (3/9 - 33%; two lung and one kidney), HRAS (1/9 - 11%; lung), KRAS (2/9 - 22%; one colon and one lung), NRAS (3/9 - 33%; two lung and one kidney) and PIK3CA (2/9 - 22%; one melanoma and one lung). This evidence concerns the gene PIK3CA and melanoma.