These results, showing that myosin VI is required for lamellipodia extension and ruffle formation in HeLa cells, were confirmed and quantified in more motile cells, namely A549, the human lung adenocarcinoma epithelial cell line, which extend very prominent lamellipodia that are covered in dorsal ruffles (Figure 1C). This evidence concerns the gene MYO6 and lung adenocarcinoma.