The present study was therefore conducted to determine the time course of endothelial NOS (eNOS), neuronal NOS (nNOS), inducible NOS (iNOS), 3-nitrotyrosine (3-NT), an index of protein nitration and ONOO-, as well as PAR in lung tissue using an established ovine model of sepsis induced by ALI and instillation of live Pseudomonas bacteria into the lungs [8]. This evidence concerns the gene NOS3 and acute respiratory distress syndrome.