Previous studies revealed the important roles of the different isoforms of nitric oxide (NO) synthases (NOS), peroxynitrite (ONOO-), and poly-ADP ribose (PAR) in the pathophysiology of cardiopulmonary derangements induced by acute lung injury (ALI) and sepsis, thereby offering potentially new treatment options such as inhibition of NOS [5], decomposition catalyzation of ONOO- [6], or inhibition of PAR polymerase (PARP) [7]. Here, NOS2 is linked to acute lung injury.