ECRG4 and central nervous system cancer: Previous studies reported promoter hypermethylation and reduced expression of ECRG4 in advanced esophageal, prostate carcinomas, colorectal carcinoma, and glioma[3,11,12] Together with a study in esophageal cancer cell lines[4], these reports suggest that ECRG4 may play a tumor suppressor role in certain cancers including glioma.