Recent studies have demonstrated that endogenous nucleic acids may activate plasmacytoid dendritic cells (pDC) via TLR7 and TLR9, leading to the production of Type I interferons (INFα/β) [7], that may drive many of the clinical features of systemic lupus erythematosis (SLE) [8]. Here, TLR7 is linked to systemic lupus erythematosus.