However, unlike these previous reports that demonstrated the CXCR2 signaling axis to be an important determinant of immune cell infiltration or function within the CNS, blocking CXCR2 signaling during chronic JHMV-induced disease did not influence the infiltration of the traditional mediators of JHMV – induced demyelination, namely T – lymphocytes and macrophages [33], [34]. The gene discussed is CXCR2; the disease is Peripheral demyelination.