CXCR2 and Peripheral demyelination: To assess a functional role for signaling by ELR+ chemokines during chronic viral – induced demyelination, JHMV infected C57BL/6 mice were treated with CXCR2 neutralizing antiserum or control serum (NRS) from days 12–20 p.i, after which mice were allowed to recover until day 35 p.i. Administration of anti-CXCR2 treatment resulted in sustained clinical disease compared to mice treated with control antiserum (Figure 2A).