Conversly, in obliterative bronchiolitis [20], matrilisyn showed a protective role in chronic lung injury, regulating a population of CD103+ DC that limit acute inflammation and inhibit progression of pulmonary fibrosis [21]; as well as repairing airway epithelium and re-epithelialization of airway wounds by facilitating cell migration. The gene discussed is ITGAE; the disease is pulmonary fibrosis.